Compositions and Methods for Restoring or Rejuvenating Stem/Progenitor Cell Function

A method of restoring or rejuvenating adult muscle-derived stem/progenitor cell (MDSPC) function to treat, delay, prevent, or ameliorate one or more symptoms associated with aging in a mammal in need thereof, comprising:

• administering an exogenous amount of isolated young allogeneic MDSPCs in combination with one or more inhibitors of mechanstic target of rapamycin (mTOR) and/or inhibitor of kappa B kinase/nuclear factor kappa-light-chain-enhancer of activated B cells (IKK/NF-κB) to said mammal, wherein said isolated young allogeneic MDSPCs secrete or release regulatory factors selected from the group consisting of:
• recombination signal binding protein for immunoglobulin kappa J regeion (RBP-JK) inhibitory factor, Stanniocalcin-1, Wingless-Type MMTV Integration Site Family, Member 3A (Wnt3a), KLOTHO, C-C motif chemokine (CCL11), micro-RNA (miRNA)-489, vascular endothelial growth factor (VEGF), and hepatocyte growth factor (HGF), insulin-like growth factor (IGF), and human epidermal growth factor receptor 2 (Hwe2/neu;
• wherein said one or more secreted or released stimulatory factors restore or rejuvenate said adult MDSPC function and treat, delay, prevent, or ameliorate one or more symptoms associated with aging.