Back to results
US 2016/0243166 A1Published application
Multipotent stem cells and uses thereof
AssigneeThe Brigham and Women's Hospital, Inc.
InventorsKeith D. Crawford, Christopher Southgate
Life of this patent
Estimating the term…
Loading patent…
Loading patent…
AssigneeThe Brigham and Women's Hospital, Inc.
InventorsKeith D. Crawford, Christopher Southgate
Estimating the term…
The invention provides a quiescent stem cell having the capacity to differentiate into ectoderm, mesoderm and endoderm, and which does not express cell surface markers including MHC class I, MHC class II, CD44, CD45, CD13, CD34, CD49c, CD73, CD105 and CD90. The invention further provides a proliferative stem cell, which expresses genes including Oct-4, Nanog, Sox2, GDF3, P16INK4, BMI, Notch, HDAC4, TERT, Rex-1 and TWIST but does not express cell surface markers including MHC class I, MHC class II, CD44, CD45, CD13, CD34, CD49c, CD73, CD105 and CD90. The cells of the invention can be isolated from adult mammals, have embryonic cell characteristics, and can form embryoid bodies. Methods for obtaining the stem cells, as well as methods of treating diseases and the differentiated stem cells, are also provided.
A method of enhancing recovery from joint surgery, comprising administering to the joint during surgery to repair the joint a composition comprising stem or progenitor cells in an amount effective to enhance recovery, and a pharmaceutically acceptable carrier.
A method of differentiating a stem or progenitor cell, the method comprising:
Dependencies are inferred from the claim text.