Phosphate binder formulation for simple dosing

20:

• A pharmaceutical composition for treating a renally insufficient patient having hyperphosphatemia comprising untableted granules containing at least one effervescent agent and, at a weight ratio of 1:1 to 4:1, calcium acetate and magnesium carbonate.

21:

• The composition of claim 20 wherein the granules have an average particle size of 100-3500 μm with a taste-masking coating thereon, wherein the taste masking coating comprises at least one phosphate binding substance and at least one effervescent agent containing a carbonate and a solid organic edible acid or the acidic salt thereof.

22:

• The composition of claim 21, wherein the carbonate is an alkali or alkaline earth carbonate or an alkali or alkaline earth bicarbonate.

23:

• The composition of claim 21, wherein the phosphate-binding substance is a calcium salt, a magnesium salt, an ion exchanger polymer, a lanthanum compound, or an iron compound.

24:

• The composition of claim 21, wherein the phosphate binding substance is calcium acetate.

25:

• The composition of claim 21, wherein the coating is a spray coating.

26:

• The composition of claim 21, wherein the coating is a melt coating.

27:

• The composition of claim 21, wherein the coating is a spray coating of suspensions and/or solutions.

28:

• The composition of claim 21, wherein the carbonate is magnesium carbonate.

29:

• The composition of claim 21, wherein the granules further contain at least one sugar alcohol.

30:

• The composition of claim 21, wherein the phosphate-binding substance constitutes 15-80% of the weight of the composition.

31:

• The composition of claim 21, wherein the effervescent agent constitutes 3-60% of the weight of the composition.

32:

• The composition of claim 21 in the form of a unit dose containing 0.5-5 g of the granules.

33:

• The composition of claim 21, in the form of a stickpack containing 0.5-4 g of the granules.