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US 2016/0243141 A1Published application
Self-Assembled Brush Block Copolymer-Nanoparticles for Drug Delivery
AssigneeUniversity of Connecticut
InventorsXiuling LU, Rajeswari KASI, Thanh-Huyen TRAN, Chi Thanh NGUYEN, Prashant DESHMUKH
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Abstract
The invention provides amphiphilic liquid crystalline brush block copolymers that can readily self-assemble to nanoparticles in aqueous solutions and also allow for encapsulation of hydrophobic pharmaceutically active molecules.
Claims26
A block copolymer comprising:
- a first block, which is of formula:
- and a second block, which is of formula:
- wherein
- m and n are independently an integer about 3 to about 500;
- A is independently selected from polynorbonene, polycyclopentene, polycyclooctene, polyacrylate, polymethacrylate, and a polysiloxane;
- R1 is a steroid moiety optionally comprising a linker;
- and
- R2 is a polyalkylene oxide moiety.
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Dependencies are inferred from the claim text.