Anti-Inflammatory Compounds and Use Thereof

A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of Formula (I):

• or a salt thereof, wherein
• A is an optionally substituted aliphatic, alicyclic, aryl, aralkyl, heteroaliphatic, heterocyclic, or heteroaromatic group;
• X1 is selected from —O—, —NH—, and —S—, wherein either X1 is —NH— or A is a radical of a non-steroidal anti-inflammatory compound;
• B is an aliphatic, alicyclic, heteroaliphatic, heterocyclic, aralkyl, or heteroaromatic group optionally substituted with one or more X2 moieties, with the proviso that B is not described by
• each X2 is, independently, selected from hydrogen, halogen, hydroxyl, alkoxyl, —CN;
• an optionally substituted aliphatic, alicyclic, heteroaliphatic, heterocyclic, aryl, aralkyl, or heteroaromatic moiety;
• —ORR, —S(═O)—Rd, —NRbRc, —C(═O)Ra and —C(═O)ORa;
• n is 0-2;
• Ra, for each occurrence, is independently selected from hydrogen and an optionally substituted aliphatic, alicyclic, heteroaliphatic, heterocyclic, aryl, aralkyl, or heteroaromatic moiety;
• each of Rb and Rc, for each occurrence, is independently selected from hydrogen;
• hydroxyl, SO2Rd, and an aliphatic, alicyclic, heteroaliphatic, heterocyclic, aryl, aralkyl, heteroaromatic or acyl moiety;
• Rd, for each occurrence, is independently selected from hydrogen, —N(Re)2, aliphatic, aryl and heteroaryl,
• Re, for each occurrence, is independently hydrogen or aliphatic;
• and
• RR is an optionally substituted aliphatic, alicyclic, heteroaliphatic, heterocyclic, aryl, aralkyl, heteroaromatic or acyl moiety;
• and
• D is —O—P(O)(ORf)2 or —O—P(ORg)2, wherein each Rf and Rg is a substituted or unsubstituted alkyl of 1-6 carbon atoms.