Topical pharmaceutical compositions containing nanodroplets for the treatment of psoriasis
AssigneeCadila Healthcare Limited
InventorsSunilendu Bhushan ROY, Jay Shantilal KOTHARI, Shafiq SHEIKH, Jitendra Dasharathlal PATEL, Jinesh Suresh PANCHOLI
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Abstract
Stable pharmaceutical compositions and processes for making same for the treatment of psoriasis. The compositions may be nanoemulsions having nano size droplets of one or more anti-psoriasis agents, e.g. clobetasol and/or salicylic acid. The compositions exhibit improved permeability and bioavailability.
Claims23
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A stable topical pharmaceutical nanogel composition of clobetasol or a salt or ester thereof, the nanogel composition consisting of a nanoemulsion and a gel base, the nanoemulsion consists of nano size droplets of clobetasol or a salt or ester thereof, 5% to 20% by weight of the composition of oils or lipids, 0.1% to 10% by weight of emulsifiers, and a pharmaceutically acceptable excipient.
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A stable topical pharmaceutical nanogel composition of clobetasol or a salt or ester thereof and salicylic acid or a salt or ester thereof, the nanogel composition consisting of a nanoemulsion and a gel base, the nanoemulsion consists of nano size droplets of clobetasol or a salt or ester thereof and salicylic acid or a salt or ester thereof, 5% to 20% by weight of the composition of oils or lipids, 0.1% to 10% by weight of emulsifiers, and a pharmaceutically acceptable excipient.
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Dependencies are inferred from the claim text.