Processes For Preparing Morphinan-6-One Products With Low Levels Of Alpha, Beta-Unsaturated Ketone Compounds
AssigneeMallinckrodt Inc.
InventorsHenry J. Buehler, William E. Dummitt, Anthony Mannino, Dennis C. Aubuchon, Hong Gu
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Abstract
The present invention generally relates to processes for preparing highly pure morphinan-6-one products. The processes involve reducing the concentration of alpha, beta unsaturated ketone compounds present as impurities in morphinan 6 one products or reaction mixtures including morphinan 6 one compounds by treatment with a sulfur-containing compound.
Claims21
-50. (canceled)
A composition comprising oxymorphone and containing about 0.001% or less, by weight of said oxymorphone, of an α,β unsaturated ketone.
A pharmaceutical formulation comprising oxymorphone and containing about 0.001% or less, by weight of said oxymorphone, of an α,β unsaturated ketone.
Dependencies are inferred from the claim text.