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US 2016/0243097 A1Published application
Methods of treating poxviral infections
AssigneesEmergent Virology LLC, University of Oxford
InventorsUrban RAMSTEDT, Brennan KLOSE, Nicole ZITZMANN, Raymond A. DWEK, Terry D. BUTTERS
Life of this patent
Estimating the term…
Abstract
Provided are methods of treating a disease or condition caused by or associated with a virus belonging to the Poxviridae family using iminosugars, such as DNJ derivatives.
Claims19
A method of treating or preventing a disease or condition caused by or associated with a virus belonging to the Poxviridae family, the method comprising administering to a subject in need thereof an effective amount of a compound of the formula,
- or a pharmaceutically acceptable salt thereof,
- wherein R is either selected from substituted or unsubstituted alkyl groups, substituted or unsubstituted cycloalkyl groups, substituted or unsubstituted aryl groups, or substituted or unsubstituted oxaalkyl groups;
- or wherein R is
- R1 is a substituted or unsubstituted alkyl group;
- X1-5 are independently selected from H, NO2, N3, or NH2;
- Y is absent or is a substituted or unsubstituted C1-alkyl group, other than carbonyl;
- and
- Z is selected from a bond or NH;
- provided that when Z is a bond, Y is absent, and provided that when Z is NH, Y is a substituted or unsubstituted Ci-alkyl group, other than carbonyl;
- and
- wherein W1-4 are independently selected from hydrogen, substituted or unsubstituted alkyl groups, substituted or unsubstituted haloalkyl groups, substituted or unsubstituted alkanoyl groups, substituted or unsubstituted aroyl groups, or substituted or unsubstituted haloalkanoyl groups.
8 more elements
A method of infectivity of a cell infected with a virus belonging to the Poxviridae family, the method comprising
- contacting a cell infected with a virus belonging to the Poxviridae family with an effective amount of a compound of the formula,
- or a pharmaceutically acceptable salt thereof,
- wherein R is either selected from substituted or unsubstituted alkyl groups, substituted or unsubstituted cycloalkyl groups, substituted or unsubstituted aryl groups, or substituted or unsubstituted oxaalkyl groups;
- or wherein R is
- R1 is a substituted or unsubstituted alkyl group;
- X1-5 are independently selected from H, NO2, N3, or NH2;
- Y is absent or is a substituted or unsubstituted C1-alkyl group, other than carbonyl;
- and
- Z is selected from a bond or NH;
- provided that when Z is a bond, Y is absent, and provided that when Z is NH, Y is a substituted or unsubstituted C1-alkyl group, other than carbonyl;
- and
- wherein W1-4 arc independently selected from hydrogen, substituted or unsubstituted alkyl groups, substituted or unsubstituted haloalkyl groups, substituted or unsubstituted alkanoyl groups, substituted or unsubstituted aroyl groups, or substituted or unsubstituted haloalkanoyl groups.
9 more elements
Dependencies are inferred from the claim text.