Forazolines, compositions thereof and uses thereof
AssigneeWisconsin Alumni Research Foundation
InventorsTimothy BUGNI, Thomas WYCHE, David ANDES, Douglas BRAUN
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Abstract
An isolated compound of Formula I and salts thereof are provided: wherein X is Cl or Br. A compound isolated from Actinomadura and having a chemical formula of C43H69ClN4O10S2 or C43H69BrN4O10S2 is also provided. Compositions including the compounds and methods of using the compounds to treat fungal infections including those such as Candida are also disclosed.
Claims21
A pharmaceutical composition comprising an effective amount of a compound of Formula I:
- or pharmaceutically acceptable salt thereof for treating a fungal infection in a mammal, wherein X is Cl or Br;
- and
- a pharmaceutically acceptable carrier.
A pharmaceutical composition comprising an effective amount of a compound of Formula I:
- or pharmaceutically acceptable salt thereof for treating a fungal infection in a mammal, wherein X is Cl or Br;
- and
- an isotonic aqueous solution.
A pharmaceutical composition comprising an effective amount of a compound of Formula I:
- or pharmaceutically acceptable salt thereof for treating a fungal infection in a mammal, wherein X is Cl or Br;
- and
- one or more of cetyl esters wax, cetyl alcohol, white wax, glyceryl monostearate, propylene glycol monostearate, methyl stearate, benzyl alcohol, sodium lauryl sulfate, glycerin, mineral oil, carbomer, ethyl alcohol, acrylate adhesives, polyisobutylene adhesives, and silicone adhesives.
Dependencies are inferred from the claim text.