Controlled release pharmaceutical formulations of nitazoxanide
AssigneeRomark Laboratories L.C.
InventorsJean-Francois Rossignol, Marc Ayers
Life of this patent
Estimating the term…
Abstract
Solid dosage formulations of nitazoxanide or a nitazoxanide analogue are provided that comprise a controlled release portion and an immediate release portion. The pharmaceutical composition is typically in the form of a bilayer solid oral dosage form comprising (a) a first layer comprising a first quantity of nitazoxanide or analogue thereof in a controlled release formulation; and (b) a second layer comprising a second quantity of nitazoxanide or analogue thereof in an immediate release formulation. Method of using the formulations in the treatment of hepatitis C are also provided.
Claims20
A pharmaceutical composition in the form of a solid dosage form comprising:
- a) controlled release granules comprising a first quantity of nitazoxanide or an analogue thereof and b) immediate release granules comprising a second quantity of nitazoxanide or an analogue thereof
A method of reducing one or more side-effects associated with treatment with nitazoxanide or tizoxanide in a patient, the method comprising administering to the patient a therapeutically effective amount of a pharmaceutical composition in the form of a solid dosage form, the composition comprising a) controlled release granules comprising a first quantity of nitazoxanide or an analogue thereof and b) immediate release granules comprising a second quantity of nitazoxanide or an analogue thereof
A method for increasing the bioavailability of nitazoxanide or an analogue thereof in a patient, the method comprising administering to the patient a therapeutically effective amount of a pharmaceutical composition in the form of a solid dosage form, the composition comprising a) controlled release granules comprising a first quantity of nitazoxanide or an analogue thereof and b) immediate release granules comprising a second quantity of nitazoxanide or an analogue thereof
A method of extending absorption of nitazoxanide or an analogue thereof in a patient, the method comprising administering to the patient a therapeutically effective amount of a pharmaceutical composition in the form of a solid dosage form, the composition comprising a) controlled release granules comprising a first quantity of nitazoxanide or an analogue thereof and b) immediate release granules comprising a second quantity of nitazoxanide or an analogue thereof.
Dependencies are inferred from the claim text.