Use of an aromatase inhibitor for the treatment of hypogonadism and related diseases
AssigneeMereo BioPharma 2 Limited
InventorsAnn Taylor, Lloyd B. Klickstein
Life of this patent
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Abstract
The aromatase inhibitor 4,4′-[fluoro-(1-H-1,2,4-triazol-1-yl)methylene]bisbenzonitrile increases testosterone levels and treats hypogonadism and related diseases. A particular dosing regimen is disclosed as well as pharmaceutical compositions comprising said of 4,4′-[fluoro-(1-H-1,2,4-triazol-1-yl)methylene]bisbenzonitrile, optionally in combination with other active ingredients and kits comprising the pharmaceutical compositions.
Claims22
1-78. (canceled)
A method for the treatment of a male patient with serum total testosterone levels below 400 ng/dl and in need of increased testosterone levels comprising administering to said patient an effective amount of the compound 4,4′-[fluoro-(1-H-1,2,4-triazol-1-yl)methylene]bisbenzonitrile, wherein the effective amount of the compound is from about 0.0005 mg to about 5.0 mg per dose, and wherein the compound is administered according to a dosing regimen having a dosing periodicity selected from about one dose once weekly to about one dose once every month.
Dependencies are inferred from the claim text.