4-Methylpyrazole Formulations for Inhibiting Ethanol Intolerance

A method of reducing a symptom associated with acetaldehyde accumulation accompanying ethanol consumption in a subject with reduced or absent aldehyde dehydrogenase subtype 2 (ALDH2) activity comprising administering an effective amount of 4-MP that reduces acetaldehyde accumulation by about 50% to about 60% as compared to a subject not administered 4-MP, wherein about 0.1 mg to about 1.0 mg 4-MP per kilogram of the subject's body mass is administered.

A method of ameliorating a symptom of acetaldehyde accumulation accompanying ethanol consumption in a subject with reduced or absent aldehyde dehydrogenase subtype 2 (ALDH2) activity comprising administering an amount of 4-MP or a physiologically acceptable salt of 4-MP effective to reduce or inhibit ethanol-oxidizing activity of alcohol dehydrogenase in the subject, wherein about 0.1 mg to about 1.0 mg 4-MP per kilogram of the subject's body mass is administered.

A method for reducing a risk in a subject for a disease or disorder caused by exposure to acetaldehyde in a subject with reduced or absent aldehyde dehydrogenase subtype 2 (ALDH2) activity comprising administering an amount of 4-MP or a physiologically acceptable salt of 4-MP effective to increase catabolism of acetaldehyde in the subject, wherein increasing catabolism of acetaldehyde reduces the risk for the disease or disorder.