Methods and Compositions for Improving Cognitive Function
AssigneeMars, Incorporated
InventorsStephen FRENCH, Amar P. INAMDAR, Ian Andrew MACDONALD, Susan T. FRANCIS
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Abstract
This invention relates to compositions, and methods of use thereof, for (i) enhancing executive cognitive function(s) (for example, decision making, planning, working memory, multitasking, judgment, numerical problem-solving, reading comprehension), and/or (ii) increasing blood flow in brain vasculature, comprising administering to a subject in need thereof, certain polyphenols such as flavanols, procyanidins, or pharmaceutically acceptable salts or derivatives thereof.
Claims20
A method of enhancing executive cognitive function in a subject in need thereof comprising administering to the subject a composition comprising an effective amount of at least one compound selected from the group of catechin, epicatechin, a compound having the formula An, a pharmaceutically acceptable salt thereof, and a derivative thereof:
- wherein
- n is an integer from 2 to 18;
- R and X each have either α or β stereochemistry;
- R is OH, O-sugar or O-gallate;
- the substituents of C-4, C-6 and C-8 are X, Z and Y, respectively, and bonding of monomeric units occurs at C-4, C-6 or C-8;
- when any C-4, C-6 or C-8 is not bonded to another monomeric unit, X, Y and Z are hydrogen or a sugar;
- and
- the sugar is optionally substituted with a phenolic moiety at any position, for instance, via an ester bond.
A method of increasing blood flow in brain vasculature in a healthy subject in need thereof comprising administering to the subject a composition comprising an effective amount of at least one compound selected from the group of catechin, epicatechin, a compound having the formula An, a pharmaceutically acceptable salt thereof, and a derivative thereof:
- wherein
- n is an integer from 2 to 18;
- R and X each have either α or β stereochemistry;
- R is OH, O-sugar or O-gallate;
- the substituents of C-4, C-6 and C-8 are X, Z and Y, respectively, and bonding of monomeric units occurs at C-4, C-6 or C-8;
- when any C-4, C-6 or C-8 is not bonded to another monomeric unit, X, Y and Z are hydrogen or a sugar;
- and
- the sugar is optionally substituted with a phenolic moiety at any position, for instance, via an ester bond.
Dependencies are inferred from the claim text.