Solid compositions of triglycerides and uses thereof
OwnerJohn KLOPP, Gabrielle MORRIS +2inventors
InventorsJohn KLOPP, Gabrielle MORRIS, Emil KAKKIS, Steven JUNGLES
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Abstract
The present invention includes solid compositions of triglycerides with one or more fatty acids, such as triheptanoin and glycerol phenylbutyrate, and therapeutic use thereof. The solid compositions can be prepared by spray-drying or other processes.
Claims49
A solid composition comprising triglycerides with one or more fatty acids as an active ingredient and a solid substance;
- wherein the active ingredient has purity greater than 95% and the solid composition comprises at least about 50% by weight the triglycerides.
The solid composition of any of the preceding claims, wherein the solid substance further comprises one or more sustained release polymers.
The solid composition of any of the preceding claims, which is in form of a powder.
A solid composition comprising a plurality of solid particles, each particle comprising triglycerides with one or more fatty acids as an active ingredient adsorbed onto a solid substance;
- wherein the active ingredient has purity greater than 95% and the solid composition comprises at least about 50% by weight the triglycerides.
The solid composition of any one of the preceding claims, which further comprises a pharmaceutically acceptable excipient.
The solid composition of any one of the preceding claims, wherein the active ingredient has purity greater than 97% after about four weeks of exposure to about 25° C. at about 60% relative humidity when package in a sealed container.
The solid composition of any one of the preceding claims, wherein the composition has a water content of no more than 0.35% by weight after about four weeks of exposure to about 25° C. at about 60% relative humidity when package in a sealed container.
The solid composition of any one of the preceding claims, wherein the active ingredient has purity greater than 97% after about four weeks of exposure to about 40° C. at about 75% relative humidity when package in a sealed container.
The solid composition of any one of the preceding claims, wherein the composition has a water content of no more than 0.45% by weight after about four weeks of exposure to 40° C. at about 75% relative humidity when package in a sealed container.
Dependencies are inferred from the claim text.