Novel oral pharmaceutical compositions of treprostinil
AssigneeGavis Pharmaceuticals
InventorsAman Trehan, James Garegnani
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Abstract
Oral pharmaceutical compositions of treprostinil, a prodrug, or a pharmaceutically acceptable salt thereof are provided. The compositions possess absolute oral bioavailability of greater than 10% and achieve circulating concentrations when administered orally. Methods of treating prostacyclin responsive conditions including pulmonary arterial hypertension (PAH) by administering such compositions also are provided.
Claims14
An oral pharmaceutical composition comprising treprostinil free acid, a prodrug or a pharmaceutically acceptable salt thereof excluding the diethanolamine salt, and one or more pharmaceutically acceptable carriers.
Dependencies are inferred from the claim text.