Surface functionalized, host-guest polymer nano-assemblies and methods thereof
OwnerSankaran Thayumanavan, Jiaming Zhuang +1inventors
InventorsSankaran Thayumanavan, Jiaming Zhuang, Hui Wang
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Abstract
The invention generally relates to polymer-based nano-structures. More particularly, the invention relates to novel, surface-functionalized, guest-host polymer nano-assemblies and nano-delivery vehicles useful in diverse fields including drug delivery, diagnostics and specialty materials. The nano-assemblies and nano-delivery vehicles of the invention are afforded via simplify and reliable approaches.
Claims25
A nano-assembly comprising:
- a host crosslinked polymer network having a functionalized surface with one or more functional groups;
- and
- a guest molecular cargo non-covalently encapsulated in the host crosslinked polymer network,
- wherein the host crosslinked polymer network is addressable by a biological or chemical intervention resulting in partial or complete decrosslinking of the host polymer network and release of the guest molecular cargo from the nano-assembly.
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21-32. (canceled)
A method for controlled delivery of an agent to a target biological site, comprising:
- providing a nano-assembly of a host crosslinked polymer network non-covalently encapsulating therein a guest molecular cargo, wherein the host crosslinked polymer network is capable of partial or complete decrosslinking by a biological or chemical intervention resulting in release of the guest molecular cargo from the nano-assembly;
- delivering the nano-assembly to the target biological site;
- and
- causing a biological or chemical intervention resulting in a partial or complete decrosslinking resulting in release of the guest molecular cargo from the nano-assembly.
34-51. (canceled)
A nanoparticle comprising:
- a shell of a crosslinked polymer network having a surface functionalized with one or more functional groups;
- and
- a core comprising a host polymer network and a guest agent non-covalently encapsulated therein,
- wherein the core, the shell, or one or more intervening layers of the crosslinked polymer network are independently addressable by a biological or chemical intervention resulting in partial or complete disassembly of the shell, the one or more intervening layers, and/or the core thereby releasing of the guest agent.
53-92. (canceled)
Dependencies are inferred from the claim text.