Back to results
US 2016/0239960 A1Published application
Biomarker method
AssigneeThe University of Manchester
InventorsRichard John Byers, Christopher Rose
Life of this patent
Estimating the term…
Loading patent…
Loading patent…
AssigneeThe University of Manchester
InventorsRichard John Byers, Christopher Rose
Estimating the term…
Provided herein is a computer-implemented method for quantifying the spatial distribution of cells or sub-cellular structures, the method comprising the following steps performed by a computer: (a) receiving for a subject image data comprising a plurality of biomarkers, N, wherein the data represents a spatial map of the biomarkers; (b) processing the data to obtain a set of coordinates, wherein each coordinate denotes the location of a cell or sub-cellular structure represented by a biomarker or combination of biomarkers; (c) processing the set of coordinates into a two-dimensional symmetric (2N−1)×(2N−1) or 2N×2N matrix (D), wherein each element (i, j) of the matrix indicates the frequency of a cell or sub-cellular structure represented by a first biomarker or combination of biomarkers (i) being observed within an interaction distance, di, of a cell or sub-cellular structure represented by a second biomarker or combination of biomarkers (j), and wherein i and j may be the same or different; and (d) using a classifier to assign the subject to a group or category based on the two-dimensional symmetric matrix (D).
A computer-implemented method for quantifying the spatial distribution of cells or sub-cellular structures, the method comprising the following steps performed by a computer:
The method of any preceding claim, wherein the classifier is a statistical classifier.
The method of any preceding claim, wherein the classifier is a voting classifier.
The method of any preceding claim, wherein the set of coordinates in step (b) are a set of (x,y) coordinates.
The method of any preceding claim, wherein the frequency is the relative frequency.
The method of any preceding claim, wherein the image data is obtained from a tissue sample.
The method of any preceding claim, wherein N is at least two.
Use of the method according to any preceding claim, for forming and/or testing scientific hypotheses for one or more interventions.
Apparatus comprising at least one processor configured to perform a method for quantifying the spatial distribution of cells or sub-cellular structures comprising:
A computer-implemented method for quantifying the spatial distribution of cells or sub-cellular structures, the method comprising the following steps performed by a computer:
Dependencies are inferred from the claim text.