Biomarkers for memory loss
AssigneesGeorgetown University, University of Rochester
InventorsHoward J. FEDEROFF, Mark E. MAPSTONE, Amrita K. CHEEMA, Massimo S. FIANDACA
Life of this patent
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Abstract
The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's lipidomic profile, and comparing the value of the subject's lipidomic profile with the value of a normal lipidomic profile. A decrease in the value of the subject's lipidomic profile over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.
Claims12
A method of determining if a subject has an increased risk of suffering from memory impairment, the method comprising
- a) analyzing at least one plasma sample from the subject to determine a value of the subject's lipidomic profile, and
- b) comparing the value of the subject's lipidomic profile with the value of a normal lipidomic profile, to determine if the subject's lipidomic profile is reduced compared to a normal lipidomic profile,
- wherein a decrease in the value of the subject's lipidomic profile is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.
A method of monitoring the progression of memory impairment in a subject, the method comprising
- a) analyzing at least two plasma samples from the subject with each sample taken at different time points to determine the values of each of the subject's lipidomic profiles, and
- b) comparing the values of the subject's lipidomic profiles over time to determine if the subject's lipidomic profile is declining over time,
- wherein a decline in the subject's lipidomic value over time is indicative that the subject's risk of suffering from memory impairment is increasing over time.
A method of monitoring the progression of a treatment for memory impairment in a subject, the method comprising
- a) analyzing at least two plasma samples from a subject undergoing treatment for memory impairment with each sample taken at different time points to determine the values of each of the subject's lipidomic profiles, and
- b) comparing the values of the subject's lipidomic profiles over time to determine if the subject's lipidomic profile is changing over time,
- wherein a decline in the subject's lipidomic value over time is indicative that the treatment for memory impairment is not effective and wherein an increase in the subject's lipidomic value over time is indicative that the treatment for memory impairment is effective in treating memory impairment in the subject.
Dependencies are inferred from the claim text.