Biosensor Membrane Composition, Biosensor, and Methods for Making Same
AssigneeMicrochips Biotech, Inc.
InventorYanan Zhang
Life of this patent
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Abstract
Selectively permeable membranes for biosensors are provided. In one embodiment, the membrane includes a polymer mixture that includes a polyurethane component, a siloxane component, and a hydrogel component, the components in the mixture in amounts of about 60 to about 80 wt % polyurethane, about 10 to about 20 wt % siloxane, and about 10 to about 20 wt % hydrogel. The membrane has a surface restructured to be hydrophilic, with the restructured surface being crosslinked via reactive end groups on at least one of the polyurethane, the siloxane, and the hydrogel components.
Claims26
A selectively permeable membrane for a biosensor, comprising:
- a polymer mixture which comprises a polyurethane component, a siloxane component, and a hydrogel component, the components being present in the mixture in amounts of about 60 to about 80 wt % polyurethane, about 10 to about 20 wt % siloxane, and about 10 to about 20 wt % hydrogel,
- wherein the membrane has a surface restructured to be hydrophilic, and the polymer mixture of the membrane with the restructured surface is crosslinked via reactive end groups on at least one of the polyurethane component, the siloxane component, and the hydrogel component.
A biosensor comprising:
- a substrate;
- at least one electrode disposed on the substrate;
- at least one enzyme layer disposed on the at least one electrode;
- and
- at least one selectively permeable membrane fixed on the at least one enzyme layer, wherein the at least one selectively permeable membrane comprises a polymer mixture which comprises a polyurethane component, a siloxane component, and a hydrogel component, the components being present in the mixture in amounts of about 60 to about 80 wt % polyurethane, about 10 to about 20 wt % siloxane, and about 10 to about 20 wt % hydrogel,
- wherein the at least one selectively permeable membrane has a surface restructured to be hydrophilic, and the polymer mixture of the membrane with the restructured surface is crosslinked via reactive end groups on at least one of the polyurethane component, the siloxane component, and the hydrogel component.
A method for making a selectively permeable membrane comprising:
- mixing a polyurethane component, a siloxane component, and a hydrogel component together with a first solvent for the components to form a polymer solution mixture;
- depositing the polymer solution mixture on a substrate;
- evaporating the first solvent from the polymer solution mixture to form a film of a polymer mixture, the film having a surface opposing the substrate;
- applying a solvent mixture onto the surface of the film to partially re-dissolve and swell the film, wherein the solvent mixture comprises a hydrophilic constituent and a hydrophobic constituent;
- and
- evaporating the solvent mixture from the partially redissolved and swollen film to reform the surface with hydrophilic molecules of the polymer mixture redistributed toward the reformed surface.
A biosensor comprising:
- a substrate;
- at least one electrode disposed on the substrate;
- at least one enzyme layer disposed on the at least one electrode;
- and
- at least one selectively permeable membrane fixed on the at least one enzyme layer, wherein the at least one selectively permeable membrane comprises a solvent cast film which comprises a mixture of a first polyether-based thermoplastic polyurethane copolymer, and a polyether-based polyurethane copolymer, wherein the polyether-based thermoplastic polyurethane copolymer, or the polyether-based polyurethane copolymer, or both comprise at least one siloxane repeat unit.
A method for making a selectively permeable membrane comprising:
- applying onto a substrate a polymer solution mixture which comprises a mixture of a first polyether-based thermoplastic polyurethane copolymer, and a polyether-based polyurethane copolymer, wherein the polyether-based thermoplastic polyurethane copolymer, or the polyether-based polyurethane copolymer, or both comprise at least one siloxane repeat unit, in solution with a volatile organic solvent;
- and
- evaporating the volatile organic solvent from the polymer solution mixture to form a film of a polymer mixture on the substrate.
Dependencies are inferred from the claim text.