Multi-photon systems and methods
AssigneeInvenio Imaging, Inc.
InventorsChristian Wilhelm FREUDIGER, Jay Kenneth TRAUTMAN
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Abstract
The present disclosure provides systems and methods for performing multi-photon imaging using a fiber laser. Systems and methods herein may be used for performing imaging using multi-photon excitation (e.g., using two-photon excitation or multi-color two-photon excited fluorescence). Aspects of the disclosure are applicable to a variety of multi-photon methods without being limited to CRS or multi-photon fluorescence excitation. A multi-wavelength fiber laser system and its use in multi-photon methods are provided.
Claims26
A multi-photon excitation system, comprising:
- a first fiber system, seeded by a first input train of pulses, generating a first output train of pulses at a first center wavelength λ1,
- a second fiber system, seeded by a second input train of pulses, generating a second output train of pulses at a second center wavelength λ2, wherein:
- (a) the first and the second output trains of pulses are temporally synchronized,
- (b) λ1≠λ2, and
- (c) multi-photon excitation is due to absorption of at least one photon of the first output train of pulses and at least one photon of the second output train of pulses;
- and
- a focusing optic that focuses the first and the second output trains of pulses into a common focal volume.
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A multi-photon imaging system comprising:
- a pulsed seed laser system;
- a beam-scanning system;
- and
- a fiber delivery system for delivering light from the pulsed seed laser system to the beam-scanning system, wherein at least one wavelength of the light from the pulsed seed laser system has a power at an input of the fiber delivery system that is less than a power at an input of the beam-scanning system, and wherein a laser duty factor of the light at the input of the beam-scanning system is larger than 100.
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Dependencies are inferred from the claim text.