Genetic Markers for Antipsychotic Induced Weight Gain and Methods for Use Thereof
AssigneeCentre for Addiction and Mental Health
InventorsClement C. Zai, James L. Kennedy, Daniel J. Mueller
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Abstract
Provided is a method of predicting a subject's weight response to antipsychotic drug treatment by obtaining a biological sample comprising genomic DNA from the subject and determining the presence or absence of one or more polymorphisms in the GABRA2 gene of the subject, wherein the presence of said one or more polymorphisms is predictive of the subject's weight change in response to antipsychotic drug treatment. The method also may comprise additional steps including treating the subject. Kits and components thereof are also provided.
Claims12
A method of predicting a subject's weight change in response to antipsychotic drug treatment comprising,
- a) obtaining a biological sample comprising genomic DNA from the subject;
- and
- b) determining the presence or absence of one or more polymorphisms in the GABRA2 gene of the subject or the complement thereof, wherein the presence of said one or more polymorphisms is predictive of the subject's weight response to antipsychotic drug treatment.
A kit comprising one or more of the following:
- a) one or more primers to amplify a nucleotide sequence that comprises the polymorphism as defined in SEQ ID NOs:1-9 or a combination thereof;
- b) one or more probes that hybridize to any one of SEQ ID NOs:1-9, over a region of nucleotides comprising the polymorphic site, wherein said probe hybridizes to a particular variant of the polymorphisms shown at the polymorphic site;
- c) one or more reagents and/or products comprising one or more buffers for performing PCR or probe hybridization, one or more DNA amplifying enzymes, or any combination thereof;
- d) one or more reagents, components and products for genotyping the polymorphisms comprising those used in exonuclease assays, nucleotide sequencing, or any combination thereof;
- e) one or more reagents, components or products for performing a DNA sequencing reaction that determines the sequence of a nucleotide sequence comprising any one of SEQ ID NOs:
- 1-2 or a combination thereof,
- f) a gene chip, or microarray comprising one or more of SEQ ID NOs:
- 1-9 or the complement thereof;
- g) one or more sets of instructions;
- or any combination thereof.
Dependencies are inferred from the claim text.