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US 2016/0237497 A1Published application
Methods and assays relating to the treatment of infection
AssigneeThe General Hospital Corporation
InventorsLaurence RAHME, Shuangchun YAN, Yok-Ai QUE, Amy TSURUMI
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Abstract
The technology described herein is directed to the diagnosis, prognosis, and treatment of infection, e.g. after burn injury.
Claims28
An assay comprising:
- Measuring the level of a gene expression product of at least one gene of Tables 4 and 5 a test sample obtained from a subject;
- wherein a decrease in the level of a gene expression product of a gene of Table 4 relative to a reference level indicates the subject has a higher risk of having or developing an infection and an increase in the level of a gene expression product of a gene of Table 5 relative to a reference level indicates the subject has a higher risk of having or developing an infection.
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A method of determining the efficacy of a treatment for infection, the method comprising:
- (a) measuring the level of a gene expression product of at least one gene of Tables 4 and 5 in a test sample obtained from a subject before administration of the treatment;
- (b) measuring the level of the gene expression product in a test sample obtained from a subject after administration of the treatment;
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- wherein the treatment is determined to be efficacious when the level of a gene expression product of a gene of Table 4 measured in step (b) is not decreased relative to the level measured in step (a) and the level of a gene expression product of a gene of Table 5 measured in step (b) is not increased relative to the level measured in step (a).
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A method of treatment for infection comprising;
- administering a treatment selected from the group consisting of:
- antibiotics;
- extended courses of antibiotics;
- immunotherapy;
- and LPS removal;
- to a subject determined to have a level of a gene expression product of a gene of Table 4 that is decreased relative to a reference level or a level of a gene expression product of a gene of Table 5 that is increased relative to a reference level.
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Dependencies are inferred from the claim text.