Methods for treating hcv

A method for determining a treatment regimen for a subject infected with Hepatitis C virus, comprising:

• (a) providing a biological sample from the subject, the sample comprising a promoter region of an IL28B gene;
• (b) detecting methylation status of at least one CpG island in the promoter region of the IL28B gene;
• and
• (c) classifying the subject as eligible to receive the direct-acting antiviral regimen for no more than 8 weeks based on the methylation status of the CpG island.

A method for identifying a risk of failure of an 8 week course of treatment with a direct-acting antiviral regimen in a Hepatitis C infected subject, comprising:

• (a) providing a sample comprising a CpG island in a promoter region of the IL28B gene from the subject;
• (b) detecting methylation status of the CpG island;
• and
• (c) identifying the subject as at risk of treatment failure if the CpG island is hypermethylated.