Method and device for the detection of molecular interactions
AssigneeClondiag GmbH
InventorsRalf Bickel, Alexandra Dworrak, Thomas Ellinger, Eugen Ermantraut, Torsten Schulz, Thomas Ullrich
Life of this patent
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Abstract
The invention relates to devices and methods for the detection of specific interactions between probe and target molecules. In particular, the invention relates to methods for the qualitative and/or quantitative detection of targets, including: introducing a sample containing targets into a reaction chamber formed between a first surface of the device and a second surface of a device, which is preferably located opposite to the first surface, wherein the distance between the first and the second surface is variable; and detecting the targets.
Claims15
1-20. (canceled)
A device, comprising:
- a detection zone defined at least in part between a first surface and a second surface, the detection zone being configured to accommodate a mixture including (a) a liquid, (b) a first complex including a first analyte and a first portion of a first optical label, and (c) a second portion of the first optical label, the second portion being in an uncomplexed state with respect to the first analyte, wherein the second portion has a greater mobility than the first complex;
- an actuator configured to vary a distance between the first surface and the second surface and thereby displace at least a portion of the mixture from between the first surface and the second surface without introducing a liquid free of the first optical label between the first surface and the second surface;
- and
- a detector configured to detect the optical label in the detection zone.
26-31. (canceled)
33-49. (canceled)
(canceled)
55-62. (canceled)
Dependencies are inferred from the claim text.