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US 2016/0237434 A1Published application
Modulation of apolipoprotein c-iii expression
AssigneeIonis Pharmaceuticals, Inc.
InventorsRosanne M. Crooke, Mark J. Graham, Kristina M. Lemonidis, Kenneth W. Dobie
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Abstract
Compounds, compositions and methods are provided for modulating the expression of apolipoprotein C-III. The compositions comprise oligonucleotides, targeted to nucleic acid encoding apolipoprotein C-III. Methods of using these compounds for modulation of apolipoprotein C-III expression and for diagnosis and treatment of disease associated with expression of apolipoprotein C-III are provided
Claims21
A compound comprising an antisense oligonucleotide, wherein said antisense oligonucleotide specifically hybridizes within nucleotides 3253-3558 of SEQ ID NO:
- 4 and consists of 15 to 30 linked nucleosides.
Dependencies are inferred from the claim text.