Compounds for inducing anti-tumor immunity and methods thereof
AssigneeCornell University
InventorsJuan R. CUBILLOS-RUIZ, Laurie H. GLIMCHER
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Abstract
Described herein is a previously unknown function of XBP1 in controlling anti-tumor immunity. It is shown that inhibiting XBP1 in tumor-associated dendritic cells inhibits tumor growth and induces protective anti-tumor immune responses.
Claims31
A method for enhancing or inducing an anti-tumor immune response in a subject, comprising administering to the subject an effective amount of a direct or indirect inhibitor of XBP1, thereby enhancing or inducing the anti-tumor immune response in the subject.
A method for treating or reducing the progression of ovarian cancer in a subject, comprising administering to the subject an effective amount of a direct or indirect inhibitor of XBP1, thereby treating or reducing the progression of ovarian cancer in the subject.
A method for enhancing or inducing the immune response of cancer-associated dendritic cells in a subject comprising administering to the subject an effective amount of a direct or indirect inhibitor of XBP1, thereby enhancing or inducing the immune response of cancer-associated dendritic cells in the subject.
A method for enhancing or inducing an anti-tumor immune response in a subject comprising administering to the subject an effective amount of a direct or indirect inhibitor of IRE1α, thereby enhancing or inducing the anti-tumor response in the subject.
Dependencies are inferred from the claim text.