US 2016/0237208 A1 · Multifunctional Degradable Nanoparticles with Control over Size and Functionalities

Abstract

In one aspect, the invention relates to polymers, crosslinked polymers, functionalized polymers, nanoparticles, and functionalized nanoparticles and methods of making and using same. In one aspect, the invention relates to degradable polymers and degradable nanoparticles. In one aspect, the invention relates to methods of preparing degradable nanoparticles and, more specifically, methods of controlling particle size during the preparation of degradable nanoparticles. In one aspect, the degradable nanoparticles are useful for complexing, delivering, and releasing payloads, including pharmaceutically active payloads. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Claims35

Dependent claims

1-21. (canceled)

A polymer produced by a method comprising a step of copolymerizing a mixture of:

a. at least one propargyl-functionalized monomer residue having an optionally substituted structure represented by a formula:
wherein Z is O, wherein R is H or C1 to C6 alkyl,
wherein m1 is an integer from 0 to 6, and
wherein n1 is an integer from 0 to 2;
and at least one of
b. at least one alkene-functionalized monomer residue having an optionally substituted structure represented by a formula:
wherein Z is O or NR, wherein R is H or C1 to C6 alkyl,
wherein m is an integer from 0 to 6, and
wherein n is an integer from 0 to 2;
c. at least one keto-functionalized monomer residue having an optionally substituted structure represented by a formula:
wherein Z is O or NR, wherein R is H or C1 to C6 alkyl, and
wherein n3 is an integer from 0 to 2;
or
d. at least one monomer residue having an optionally substituted structure represented by a formula:
wherein Z is O or NR, wherein R is H or C1 to C6 alkyl, and
wherein n2 is an integer from 0 to 2.

13 more elements

A polymer produced by a method comprising a step of copolymerizing a mixture of:

a. at least one alkene-functionalized monomer providing a residue having an optionally substituted structure represented by a formula:
wherein Z is O or NR, wherein R is H or C1 to C6 alkyl,
wherein m is an integer from 0 to 6, and
wherein n is an integer from 0 to 2;
at least one of
b. at least one keto-functionalized monomer providing a residue having an optionally substituted structure represented by a formula:
wherein Z is O or NR, wherein R is H or C1 to C6 alkyl, and
wherein n3 is an integer from 0 to 2;
or
c. at least one monomer residue having an optionally substituted structure represented by a formula:
wherein Z is O or NR, wherein R is H or C1 to C6 alkyl, and
wherein n2 is an integer from 0 to 2.

9 more elements

Dependencies are inferred from the claim text.

Facts

Application

15/049,781Filed 22 Feb 2016

Priority

5 Nov 2007

Published

18 Aug 2016

Term ends

Not estimatedThe source records don’t support an estimate.

Classification14 codes

C08G 63/912
Polymers modified by chemical after-treatment: derived from hydroxycarboxylic acids
A61K 9/0048
Galenical forms characterised by the site of application: eye, e.g. artificial tears
A61K 9/5153
Obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides:…
A61K 47/58
The modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule: obtained by reactions only…

Family

Application60/985,608Us provisional application · filed 5 Nov 2007

Application12/651,710Continuation · filed 4 Jan 2010

Application13/520,775Continuation · filed 28 Jan 2013

Application15/049,781Continuation

Application12/651,710Continuation in part

US 2011/0274620 A1Published application

US 2013/0142733 A1Published application

US 9,856,348 B2Related patent

US 2016/0237208 A1This patent

From the US filing history. Foreign family members aren’t listed.

Multifunctional Degradable Nanoparticles with Control over Size and Functionalities

Life of this patent

Multifunctional Degradable Nanoparticles with Control over Size and Functionalities

Life of this patent

Abstract

Claims35