Single-step functionalization and cross-linking of hyaluronic acid
AssigneeGalderma S.A.
InventorJean-Guy BOITEAU
Life of this patent
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Abstract
A process for manufacturing a cross-linked hyaluronic acid (HA) containing a functionalizing group including the step of reacting HA with a mixture of: (i) a first cross-linking agent selected from the group of bifunctional epoxides and polyfunctional epoxides, and (ii) a functionalized agent of a functionalizing group coupled via a 1,2,3-triazole linkage to a second cross-linking agent selected from the group of bifunctional epoxides and polyfunctional epoxides, to obtain a cross-linked HA containing the functionalizing group. The process provides a cross-linked hyaluronic acid (HA) containing a functionalizing group. The process utilizes a functionalized agent of a functionalizing group coupled via a 1,2,3-triazole linkage to a cross-linking agent.
Claims15
A process for manufacturing a cross-linked hyaluronic acid (HA) containing a functionalizing group, comprising a step of reacting HA in a single step with a mixture of:
- (i) a first cross-linking agent selected from a group consisting of bifunctional epoxides and polyfunctional epoxides, and
- (ii) a functionalized agent, consisting of a functionalizing group coupled via a 1,2,3-triazole linkage to a second cross-linking agent selected from the group consisting of bifunctional epoxides and polyfunctional epoxides, to obtain a cross-linked HA containing the functionalizing group.
A process according to claim 2, wherein the first and second cross-linking agents are independently selected from the group consisting of bifunctional epoxides and polyfunctional epoxides, and wherein the reacting step is performed at a basic pH to provide ether cross-links both between the HA and the first cross-linking agent, and between the HA and the functionalized agent.
A cross-linked hyaluronic acid containing a functionalizing group coupled to the hyaluronic acid via a 1,2,3-triazole linkage and an ether linkage, wherein the hyaluronic acid is cross-linked using the same type of ether linkage.
A functionalized agent, consisting of a functionalizing group coupled via a 1,2,3-triazole linkage to a cross-linking agent selected from bifunctional epoxides and polyfunctional epoxides.
(canceled)
Dependencies are inferred from the claim text.