Binding Moieties Based On Shark IgNAR Domains
OwnerStewart Nuttall, Victor Streltsov +8inventors
InventorsStewart Nuttall, Victor Streltsov, Katherine Merne Griffiths, Jennifer Ann Carmichael, Peter Hudson, Robert Alexander Irving, Joseph Noozhumurry Varghese, Miles Mackay Barraclough, David Peter Simmons, Kylie Anne Henderson
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Abstract
The present invention relates to immunoglobulin new antigen receptors (IgNARs) from fish and uses thereof. In particular, the present invention relates to modified IgNAR variable domains and to domains from members of the immunoglobulin superfamily that have been modified to include structural features derived from IgNAR variable domains.
Claims10
1-5. (canceled)
A method of altering a binding property of an I-set domain, said method comprising inserting a randomised loop into a region of said I-set domain wherein said region is equivalent to loop region 8 of an IgNAR variable domain.
Dependencies are inferred from the claim text.