Methods and compositions for regulatory t-cell ablation

Abstract

The present invention provides, among other things, methods and compositions for the treatment of cancer. The present invention is based, in part, on the surprising discovery that ablation of regulatory T cells (Treg), for example, transient ablation of Treg, is able to drastically reduce tumor burden and reduce metastasis when used as a single agent. In some embodiments, provided methods and compositions are used in combination with one or more other anti-tumor therapies, for example, ionizing radiation.

Dependencies are inferred from the claim text.