Binding moieties for biofilm remediation
AssigneeTrellis Bioscience, LLC
InventorsLawrence M. KAUVAR, Stefan RYSER, Angeles ESTELLES, Reyna J. SIMON
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Abstract
Binding agents able to disrupt bacterial biofilms of diverse origin are described, including monoclonal antibodies suitable for administration to a selected species, and antibody mimics including aptamer nucleic acids. Methods to prevent formation of or to dissolve biofilms with these binding agents are also described. Immunogens for eliciting antibodies to disrupt biofilms are also described.
Claims26
A monoclonal antibody (mAb), which mAb is an Fv antibody, a bispecific antibody, a chimeric antibody, species-ized antibody or a complete antibody, wherein said complete antibody comprises generic constant regions heterologous to the variable regions thereof,
- wherein said mAb
- a) has affinity for at least one DNABII protein that exceeds the affinity of said DNABII protein for components of a biofilm that includes said DNABII protein and binds DNABII protein from at least three bacterial species;
- and
- b) binds to a conformational epitope comprised in SEQ ID NO:80.
An mAb which mAb is an Fv antibody, a bispecific antibody, a chimeric antibody, species-ized antibody or a complete antibody, wherein said complete antibody comprises generic constant regions heterologous to the variable regions thereof, that
- (a) binds specifically to an epitope within positions 5-20 of any of SEQ ID NOS:71-75 or of SEQ ID NO:79 or positions 1-19 of SEQ ID NO:80 or to a peptidomimetic thereof;
- or
- (b) binds to an epitope within positions 5-20 of SEQ ID NO:76 or within positions 5-20 of SEQ ID NO:77 or within positions 5-20 of SEQ ID NO:78 or to a peptidomimetic of any of these.
A synthetic compound that mimics the epitope to which TRL1068 binds, wherein the synthetic compound mimics the conformational epitope comprised in SEQ ID NO:80.
Dependencies are inferred from the claim text.