Methods of treating alzheimer's disease with apo a-1 milano
AssigneeCedars-Sinai Medical Center
InventorPrediman K. Shah
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Abstract
This invention relates to the treatment of Alzheimer's disease, the reduction of the progression of Alzheimer's disease, and the alleviation of symptoms of Alzheimer's disease by administering ApoA-1 Milano based therapies to provide anti-inflammatory, antioxidant, and lipid depleting effects to brain tissue. In particular embodiments, the method comprises administering a composition comprising an rAAV vector encoding ApoA-1 Milano or an active fragment thereof, to a mammal having Alzheimer's disease or a symptom of Alzheimer's disease.
Claims21
A method, comprising:
- providing a composition comprising an rAAV vector encoding ApoA-1 Milano or an active fragment thereof;
- and
- administering the composition to a mammal in need of treatment for Alzheimer's disease, in need of slowing the progression of Alzheimer's disease, or in need of alleviating a symptom of Alzheimer's disease, to deliver the ApoA-1 Milano or an active fragment thereof to brain tissue, to treat the Alzheimer's disease, to slow the progression of Alzheimer's disease, or to alleviate the symptom of Alzheimer's disease.
A method of delivering ApoA1-M to brain tissue of a mammal having Alzheimer's disease or a symptom of Alzheimer's disease, comprising:
- providing a composition comprising an rAAV vector encoding ApoA-1 Milano or an active fragment thereof;
- and
- administering the composition to the mammal to deliver the ApoA-1 Milano or an active fragment thereof to the brain tissue of the mammal.
A method of reducing amyloid-beta plaques, comprising:
- providing a composition comprising an rAAV vector encoding ApoA-1 Milano or an active fragment thereof;
- and
- administering the composition to a mammal to reduce amyloid-beta plaques.
Dependencies are inferred from the claim text.