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US 2016/0237139 A1Published application
Chimeric antigen receptor
AssigneeUCL Business PLC
InventorsMartin Pulé, Kwee Yong, Lydia Lee, Ben Draper
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Abstract
The present invention provides a chimeric antigen receptor (CAR) comprising: (i) a B cell maturation antigen (BCMA)-binding domain which comprises at least part of a proliferation-inducing ligand (APRIL); (ii) a spacer domain (iii) a transmembrane domain; and (iv) an intracellular T cell signaling domain. The invention also provides the use of such a T-cell expressing such a CAR in the treatment of plasma-cell mediated diseases, such as multiple myeloma.
Claims17
A chimeric antigen receptor (CAR) which binds B-cell maturation antigen (BCMA) and comprises:
- (i) a BCMA-binding domain which comprises at least part of a proliferation-inducing ligand (APRIL);
- (ii) a spacer domain;
- and
- (iii) a transmembrane domain;
- and
- (iv) an intracellular T cell signaling domain.
3 more elements
17-18. (canceled)
Dependencies are inferred from the claim text.