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US 2016/0237136 A1Published application
NOVEL CELL LINES EXPRESSING ENaC and METHODS USING THEM
AssigneeChromocell Corporation
InventorsKambiz Shekdar, Jessica Langer, Dennis Sawchuk
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Abstract
Cell lines that stably express ENaC and methods for using those cell lines are disclosed herein. The invention includes cell lines that express various subunit combinations and various proteolyzed isoforms of ENaC and techniques for creating cell lines. The ENaC-expressing cell lines are highly sensitive, physiologically relevant and produce consistent results.
Claims30
1-40. (canceled)
An engineered cell or cell line stably expressing
- (a) an epithelial sodium channel (ENaC) alpha or delta subunit;
- (b) an ENaC beta subunit;
- and
- (c) an ENaC gamma subunit;
- wherein the cell or cell line is a mammalian cell or cell line;
- and
- wherein a functional ENaC is stably expressed.
4 more elements
Dependencies are inferred from the claim text.