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AssigneeModerna Therapeutics, Inc.
InventorsStephen G. HOGE, William Joseph ISSA, Ed MIRACCO, Jennifer NELSON, John REYNDERS, Matthew STANTON
Estimating the term…
The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them. In some aspects, the disclosure provides mRNA wherein the uracil content has been modified and which may be particularly effective for use in therapeutic compositions, because they may benefit from both high expression levels and limited induction of the innate immune response. In some aspects, the disclosure provides methods for the production of pharmaceutical compositions including mRNA without reverse phase chromatography.
1-28. (canceled)
An mRNA encoding a polypeptide, the mRNA comprising:
A method of producing a modified mRNA comprising an ORF encoding a polypeptide, the method comprising modifying an mRNA sequence to produce the modified mRNA by replacing at least one codon containing a uracil with a codon that encodes the same amino acid but contains a lower number of uracils,
A composition comprising:
Dependencies are inferred from the claim text.