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US 2016/0237118 A1Published application
Leukemia stem cell targeting ligands and methods of use
AssigneeThe Regents of the University of California
InventorsChong-xian PAN, Hongyong ZHANG
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Abstract
The present invention is directed to C-type lectin-like molecule-1 (CLL1) specific ligand peptides, comprising the amino acid motif LR(S/T), and methods of their use, e.g., for imaging detection for diagnosis of leukemia and the presence of leukemic stem cells (LSCs) and targeted therapy against leukemia mediated at least in part by CLL1-expressing LSCs.
Claims33
A peptide comprising the amino acid sequence motif LR(S/T), wherein the peptide is no longer than 10 amino acids in length and binds to C-type lectin-like molecule-1 (CLL1).
Dependencies are inferred from the claim text.