Connective tissue stimulating peptides
AssigneeOctane Orthobiologics Inc.
InventorsDennis R. Sindrey, Sydney M. Pugh, Timothy J.N. Smith
Life of this patent
Estimating the term…
Abstract
Novel peptides are described which comprise an amino acid motif selected from the group consisting of “PG”, “GP”, “PI” and “IG” and having up to 10 amino acids upstream and/or downstream of the amino acid motif, wherein “P” in the motif is proline or hydroxyproline and the peptide stimulates the development, maintenance and repair of bone, cartilage and associated connective tissue. The invention further relates to pharmaceutical compositions of these peptides, as well as therapeutic and prophylactic uses of such peptides.
Claims56
A peptide comprising an amino acid motif selected from the group consisting of “GPI”, “LPG”, “GLP”, “PIG” and “IGP” having up to 10 amino acids upstream and/or downstream of said amino acid motif, wherein “P” in said motif is proline or hydroxyproline and said peptide stimulates the development, maintenance and repair of bone, cartilage and/or associated connective tissue.
A peptide comprising an amino acid sequence represented by a formula selected from the group consisting of:
- X—(P1)mGly(P2)n, (I)
- (P1)mGly(P2)n—Z and (II)
- X—(P1)mGly(P2)n—Z;
- (III)
- wherein P1 and P2 are selected from the group consisting of proline and hydroxyproline, m=0 or 1, n=0 or 1, where m and n are independently selected;
- wherein X is selected from the group consisting of leucine, glycine-leucine, proline-isoleucine, glycine-proline-isoleucine, asparagine-glycine-leucine and proline-glycine-proline-isoleucine-glycine-proline (SEQ.ID.NO.9);
- and
- wherein Z is selected from the group consisting of isoleucine, arginine, isoleucine-glycine, isoleucine-glycine-proline, isoleucine-glycine-hydroxyproline, isoleucine-glycine-proline-proline (SEQ.ID.NO.21), isoleucine-glycine-proline-proline-glycine (SEQ.ID.NO.22), isoleucine-glycine-proline-proline-glycine-proline (SEQ.ID.NO.23), isoleucine-glycine-proline-proline-glycine-proline-arginine (SEQ.ID.NO.24), isoleucine-glycine-proline-proline-glycine-proline-arginine-glycine-arginine-threonine-glycine-aspartate-alanine (SEQ.ID.NO.25) and arginine-glycine-arginine-threonine-glycine-aspartate-alanine (SEQ.ID.NO.26).
-55. (canceled)
A method for stimulating the development, maintenance and repair of bone, cartilage and associated connective tissue in a mammal, the method comprising administering an effective amount of a peptide comprising an amino acid motif selected from the group consisting of “GPI”, “PGP”, “LPG”, “GLP”, “PIG”, and “IGP” and having up to 10 amino acids upstream and/or downstream of said amino acid motif, wherein “P” in said motif is proline or hydroxyproline.
-66. (canceled)
A system for stimulating the development, maintenance and repair of bone, cartilage and/or associated connective tissue, the system comprising:
- a peptide comprising an amino acid motif selected from the group consisting of “GPI”, “LPG”, “GLP”, “PIG” and “IGP” and having up to 10 amino acids upstream and/or downstream of said amino acid motif, wherein “P” in said motif is proline or hydroxyproline;
- and
- means for releasing the peptide to bone, cartilage and/or associated connective tissue in a controlled and sustained manner so that the peptide is delivered in a therapeutically effective amount and for a therapeutically effective time in order to stimulate the development, maintenance and repair of the bone, cartilage and/or associated connective tissue.
Dependencies are inferred from the claim text.