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US 2016/0237079 A1Published application
Modulators of Cystic Fibrosis Transmembrane Conductance Regulator
AssigneeVertex Pharmaceuticals Incorporated
InventorsSara Hadida-Ruah, Fredrick Van Goor, Mark Miller, Jason McCartney, Jinglan Zhou, Vijayalaksmi Arumugam
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Abstract
The present invention relates to modulators of cystic fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating CFTR mediated diseases using such modulators.
Claims3
1-27. (canceled)
A compound having formula I′ or formula II′:
- wherein:
- RX, ring A, Z, and q are as defined in claim 1;
- L is a linker selected from C(O) or SO2;
- p is 0 or 1;
- and
- CA is a chiral auxiliary.
3 more elements
29-66. (canceled)
Dependencies are inferred from the claim text.