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US 2016/0235833 A1Published application
Chimeric Factor H Binding Proteins (fHBP) and Methods of Use
OwnerDan M. Granoff, Peter T. Beerninkinventors
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Abstract
Chimeric fHbps that can elicit antibodies that are bactericidal for different fHbp variant strains of N. meningitidis, and methods of use, are provided.
Claims23
A non-naturally occurring fHbp of claim 1, comprising, from N-terminus to C-terminus:
- VA-I3-VB-I4-VC-I5-VD-I6-VE,
- wherein the combination of alleles for each of VA, VB, VC, VD, and VE variable segments is not found in nature.
Dependencies are inferred from the claim text.