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US 2016/0235803 A1Published application
Turmeric extract containing soft pastilles
OwnerJatin Vasant THAKKARinventor
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Abstract
The present disclosure provides a soft pastille containing turmeric extract as an active ingredient. The pastille is prepared using at least one gelling agent and at least one plasticizer in combination with pharmaceutically acceptable excipients, wherein the ratio of the gelling agent to the plasticizer is in a range of 1:2.5 to 1:3.3.
Claims15
A soft pastille comprising:
- turmeric extract in an amount ranging from 0.1 wt. % to 20 wt. % of the mass of the pastille;
- at least one gelling agent in an amount ranging from 5 wt. % to 40 wt. % of the mass of the pastille;
- at least one plasticizer in an amount ranging from 30 wt. % to 70 wt. % of the mass of the pastille;
- at least one sweetener in an amount ranging from 0.05 wt. % to 10 wt. % of the mass of the pastille;
- at least one releasing agent in an amount ranging from 0.5 wt. % to 30 wt. % of the mass of the pastille;
- at least one preservative in an amount ranging from 0.05 wt. % to 2 wt. % of the mass of the pastille;
- at least one flavouring agent in an amount ranging from 0.01 wt. % to 5 wt. % of the mass of the pastille;
- water in an amount of ranging from 5 wt. % to 20 wt. % of the mass of the pastille, and
- optionally at least one pharmaceutically acceptable excipient,
- wherein the ratio of the gelling agent to the plasticizer is in a range of 1:2.5 to 1:3.3.
7 more elements
A process for the preparation of soft pastilles;
- said process comprising the following steps:
- a. introducing 30 to 70 wt. % of a plasticizer selected from the group consisting of glycerine, sorbitol and combinations thereof and water in a reactor followed by adding 5 to 40 wt. % of a gelling agent selected from the group consisting of gelatin, carrageenan and mixtures thereof and stirring to obtain a first mixture;
- heating said first mixture at a temperature ranging from 25° C. to 85° C., preferably at 65 to 85° C. and admixing 0.5 to 30 wt. % of a releasing agent selected from the group consisting of lecithin, oil, starch and combinations thereof and optionally at least one pharmaceutically acceptable excipient to form a second mixture, wherein the ratio of the gelling agent to the plasticizer is in a range of 1:2.5 to 1:3.3;
- b. adding 0.1 to 20 wt. % of turmeric extract into glycerine to obtain slurry and mixing said slurry and the second mixture for 30 to 45 minutes at a speed of 1500 rpm to form a third mixture comprising partly dissolved and partly dispersed turmeric extract;
- c. incorporating 0.05 wt. % to 10 wt. % of at least one sweetener, 0.01 wt. % to 5 wt. % of at least one flavoring agent and 0.05 wt. % to 2 wt. % of at least one preservative into the third mixture to obtain a mass;
- and
- d. filling the mass into the preformed cavities of blister pack to obtain the pastilles.
4 more elements
Dependencies are inferred from the claim text.