Compositions containing pufa, uridine and choline and methods of use thereof
AssigneeMassachusetts Institute of Technology
InventorRichard WURTMAN
Life of this patent
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Abstract
The invention is directed to a method for increasing phosphatidylcholine in the blood of a subject comprising administering to the subject a composition having uridine or a metabolic precursor of uridine; choline or a metabolic precursor of choline; and at least one omega-3 fatty acid and/or omega-6 fatty acid, the phosphatidylcholine has a glycerol portion and the glycerol portion is bonded to two fatty acids and the total amount of carbons in the fatty acids is about 16 to 40 carbon atoms.
Claims18
A method for increasing phosphatidylcholine in the blood of a subject comprising administering to the subject a composition having uridine or a metabolic precursor of uridine;
- choline or a metabolic precursor of choline;
- and at least one omega-3 fatty acid and/or omega-6 fatty acid.
A method for increasing phosphatidylcholine in the blood of a subject comprising administering to the subject a composition having uridine or a metabolic precursor of uridine;
- choline or a metabolic precursor of choline;
- and at least one omega-3 fatty acid, wherein the phosphatidylocholine is at least one of phosphatidylcholine diacyl aa C36:6;
- phosphatidylcholine aa C38:0;
- phosphatidylcholine aa C38:6;
- phosphatidylcholine aa C40:1;
- phosphatidylcholine aa C40:2;
- phosphatidylcholine aa C40:6;
- phosphatidylcholine ae C40:6;
- or lysophosphatidylcholine (lysoPCa C18:2).
A method for increasing serum phosphatidylcholine in a subject comprising administering to the subject a composition having uridine or a metabolic precursor of uridine;
- and choline or a metabolic precursor of choline, wherein the uridine and choline are administered in a therapeutically effective amount to increase phosphatidylcholine in the serum of the subject.
A method for determining an increase in serum phosphatidylcholine in a subject comprising administering to the subject a composition having uridine or a metabolic precursor of uridine;
- and choline or a metabolic precursor of choline;
- obtaining a blood sample from the subject;
- extracting the serum from the blood sample;
- and determining the amount of phosphatidylcholine in the serum, wherein the uridine and choline are administered in a therapeutically effective amount to increase phosphatidylcholine in the serum of the subject.
Dependencies are inferred from the claim text.