Sustained-release compositions comprising topiramate and an alkalizer
AssigneeCadila Healthcare Limited
InventorsSushrut Krishnaji KULKARNI, Ajaykumar HANDA, Amit Om Prakash GUPTA
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Abstract
The present invention relates to a sustained release composition comprising topiramate and one or more pharmaceutical excipients, wherein the composition comprises a single population of beads, wherein each bead comprises: a) an inert core, b) an inner layer comprising topiramate, c) an outer layer comprising at least one sustained release material and at least one alkalizer. It also relates to methods of preparing such compositions and using those compositions in the treatment of neurological and/or psychiatric condition.
Claims22
A sustained release topiramate composition comprising a single population of beads, wherein each bead comprises:
- a) an inert core,
- b) an inner layer comprising topiramate,
- c) an outer layer comprising at least one sustained release material and at least one alkalizer, wherein the alkalizer comprises about 1 to about 60% by weight of the outer layer.
The sustained release topiramate composition according to claim further comprises one or more pharmaceutically acceptable excipients comprising fillers, binders, disintegrants, alkalizers/stabilizing agents, lubricants, wetting agents, glidants, pore forming agents and plasticizers.
Dependencies are inferred from the claim text.