Anti-bacterial applications of poly-n-acetylglucosamine nanofibers
AssigneeMarine Polymer Technologies, Inc.
InventorsJohn N. Vournakis, Sergio Finkielsztein
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Abstract
Described herein are compositions comprising shortened fibers of poly-N-acetylglucosamine and/or a derivative thereof (“sNAG nanofibers”) and anti-bacterial applications of such compositions. The sNAG nanofibers may be formulated into compositions for the prevention and/or treatment of bacterial infections and diseases associated with such infections. Regimens employing such compositions are also described.
Claims42
-29. (canceled)
A method for treating a disease or a condition associated with a bacterial imbalance in a subject in need thereof, comprising topically administering a composition comprising shortened fibers of poly-β-1→4-N-acetylglucosamine (“sNAG nanofibers”) to a subject, wherein the sNAG nanofibers are less than 10 μm in length, wherein the sNAG nanofibers comprise 70% or more than 70% of the N-acetylglucosamine monosaccharides, and wherein the sNAG nanofibers do not have an effect, or substantially have no effect, on bacterial growth or survival of Staphylococcus aureus bacterial cultures in vitro.
Dependencies are inferred from the claim text.