Combination of mtor inhibitors and pi3-kinase inhibitors, and uses thereof
AssigneeIntellikine LLC
InventorsPingda Ren, Yi Liu, Katayoun Jessen, Xin Guo, Christian Rommel, Troy Edward Wilson
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Abstract
The present invention provides for a method for treating a disease condition associated with PI3-kinase α and/or mTOR in a subject. In another aspect, the invention provides for a method for treating a disease condition associated with PI3-kinase α and/or mTOR in a subject. In yet another aspect, a method of inhibiting phosphorylation of both Akt (S473) and Akt (T308) in a cell is set forth.
Claims11
A method for treating cancer comprising administering to a subject in need thereof a therapeutically effective amount of the mTOR inhibitor:
- or a pharmaceutically acceptable salt thereof;
- and a therapeutically effective amount of the PI3-kinase α inhibitor:
- or a pharmaceutically acceptable salt thereof:
- wherein said cancer is renal cell carcinoma or endometrial cancer.
(canceled)
5-18. (canceled)
22-38. (canceled)
Dependencies are inferred from the claim text.