FORMULATIONS and PHARMACOKINETICS OF DEUTERATED BENZOQUINOLINE INHIBITORS OF VESICULAR MONOAMINE TRANSPORTER 2

A pharmaceutical composition comprising, in a solid dosage form for oral delivery of between about 100 mg and about 1 g total weight:

• between about 2% and about 18% of d6-tetrabenazine;
• between about 60% and about 70% mannitol;
• between about 15% and about 25% microcrystalline cellulose;
• between about 1% and about 10% of a polyvinylpyrrolidone;
• between about 0.5% and about 2% of a polysorbate;
• between about 5% and about 20% of a poly(ethylene oxide) polymer;
• and
• between about 0.5% and about 2% of magnesium stearate.