Disubstituted beta-lactones as inhibitors of n-acylethanolamine acid amidase (naaa)
AssigneesFondazione Istituto Italiano Di Tecnologia, Universita Degli Studi Di Parma, Universita Degli Studi Di Urbino “Carlo Bo”
InventorsDaniele Piomelli, Tiziano Bandiera, Marco Mor, Giorgio Tarzia, Fabio Bertozzi, Stefano Ponzano
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Abstract
The present invention provides compounds and pharmaceutical compositions for inhibiting N-acylethanolamine acid amidase (NAAA). Inhibition of NAAA is contemplated as a method to sustain the levels of palmitoylethanolamide (PEA) and oleylethanolamide (OEA), two substrates of NAAA, in conditions characterized by reduced concentrations of PEA and OEA. The invention also provides methods for treating inflammatory diseases and pain, and other disorders in which decreased levels of PEA and OEA are associated with the disorder.
Claims21
A method of treating a mammal suffering from a dermal disease, disorder or condition, the method comprising administering to the mammal a therapeutically effective amount of a compound having the formula:
- or a pharmaceutically acceptable salt thereof.
-6. (canceled)
-44. (canceled)
A method of treating a mammal suffering from atopic dermatitis;
- the method comprising administering to the mammal a therapeutically effective amount of a compound having the formula:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.