Indanyloxydihydrobenzofuranylacetic acids

A compound of formula (I)

• wherein:
• (Het)Ar is linked via a carbon atom and is selected from the group consisting of:
• phenyl, naphthyl, and a mono- or bicyclic heteroaromatic group having 5 to 10 ring member atoms of which 2 to 9 ring members are carbon atoms and either (i) one ring member is an unsubstituted or substituted heteroatom selected from N, NH, NRN, O, S, S(═O), and S(═O)2, (ii) one ring member is N and a second ring member is selected from N, NH, NRN, O, S, S(═O), and S(═O)2, or (iii) two ring members are N and a third ring member is selected from N, NH, NRN, O, S, S(═O), and S(═O)2,
• wherein in the naphthyl, the ring not attached to the indanyl-O atom of formula (I) optionally is partially saturated, and in the bicyclic heteroaromatic group, the ring not attached to the indanyl-O atom of formula (I) optionally is partially saturated, while the aromatic ring includes at least one heteroatom, and optionally (i) one ring member in the partially or fully saturated bridge is replaced by N, NH, NRN, O, S, S(═O), or S(═O)2, (ii) one ring member in the partially or fully saturated bridge is replaced by N, NH, or NRN and a second ring member is replaced by NH, NRN, O, S, C(═O), S(═O), or S(═O)2, or (iii) two not vicinal ring members in a fully saturated bridge are replaced by O atoms,
• wherein any of these groups is substituted with 1 group R2 or 1 NH group is replaced by an NR2 group and any of these groups is optionally and independently substituted with 1 to 4 R3 groups;
• or
• (Het)Ar is selected from the group consisting of 2,3-dihydroindole, 2,3-dihydroisoindole, 2,3-dihydrobenzofuran, 1,3-dihydroisobenzofuran, benzo[1,3]dioxole, 1,2,3,4-tetrahydroquinoline, 1,2,3,4-tetrahydroisoquinoline, chroman, isochroman, and 2,3-dihydrobenzo[1,4]dioxine, wherein any of these groups is linked via an aromatic carbon atom to the indanyloxy group in formula (I), and wherein in each of these bicyclic groups, 1 CH2 group is optionally replaced by C(═O) and each of these bicyclic groups is optionally substituted with 1 R2 group and optionally independently substituted with 1 to 4 R3 groups;
• R1 is H, F, Cl, F3C—, NC—, F3C—O—, or H3C—S(═O)2—;
• R2 is C1-6-alkyl, C2-6-alkenyl, C2-6-alkinyl, C3-6-cycloalkyl-, C1-4-alkyl-NH—, (C1-4-alkyl)2N—, C1-6-alkyl-O—, C3-6-cycloalkyl-O—, C1-4-alkyl-S—, C1-4-alkyl-S(═O)—, or C1-4-alkyl-S(═O)2, wherein each alkyl and cycloalkyl group is substituted with 1 to 3 groups independently selected from R4 and optionally substituted with 1 or more F atoms, or
• R2 is C1-4-alkyl-C(═O)—, heterocyclyl-C(═O)—, HNRN—C(═O)—, C1-4-alkyl-NRN—C(═O)—, C3-6-cycloalkyl-NRN—C(═O)—, heterocyclyl-NRN—C(═O)—, phenyl—NRN—C(═O)—, heteroaryl—NRN—C(═O)—, HO2C—, C1-4-alkyl-O—C(═O)—, C3-6-cycloalkyl-O—C(═O)—, heterocyclyl-O—C(═O)—, —NHRN, C1-4-alkyl-C(═O)NRN—, C3-6-cycloalkyl-C(═O)NRN—, heterocyclyl-C(═O)NRN—, phenyl-C(═O)NRN—, heteroaryl-C(═O)NRN—, C1-4-alkyl-S(═O)2NRN—, C3-6-cycloalkyl-S(═O)2NRN—, heterocyclyl-S(═O)2NRN—, phenyl-S(═O)2NRN—, heteroaryl-S(═O)2NRN—, heterocyclyl-O—, phenyl-O—, heteroaryl-O—, C3-6-cycloalkyl-S—, heterocyclyl-S—, phenyl-S—, heteroaryl-S—, C3-6-cycloalkyl-S(═O)—, heterocyclyl-S(═O)—, phenyl-S(═O)—, heteroaryl-S(═O)—, C3-6-cycloalkyl-S(═O)2—, heterocyclyl-S(═O)2—, phenyl-S(═O)2—, heteroaryl-S(═O)2—, HNRN—S(═O)2—, C1-4-alkyl-NRN—S(═O)2—, heterocyclyl, phenyl, or heteroaryl,
• wherein each alkyl, cycloalkyl, and heterocyclyl group is optionally substituted with 1 to 3 groups independently selected from R4 and optionally substituted with 1 or more F atoms, each phenyl and heteroaryl group is optionally substituted with 1 to 5 substituents independently selected from R5, heterocyclyl is (i) a C4-6-cycloalkyl group wherein 1 CH2 group is replaced by NRN, NR4, O, S, S(═O), or S(═O)2 and/or 1>CH— group is replaced by N, or (ii) 1 CH2 group is replaced by NRN, NR4, O, or S, and/or 1>CH— group is replaced by N, and 1 additional CH2 group is replaced by C(═O) or S(═O)2, and heteroaryl is (i) tetrazolyl, (ii) pyridinonyl, (iii) a 5-membered heteroaromatic ring containing 1 ring member selected from NRN, NR5, N, O, and S, or containing 1 N and 1 ring member selected from NRN, NR5, N, O, and S, or containing 1 NRN, NR5, N, O, or S and 2 N, or (iv) a 6-membered heteroaromatic ring which contains 1 to 3 N atoms,
• with the proviso that R2 is not C1-4-alkyl-, C1-4-alkyl-O—C1-4-alkyl, HO—C1-4-alkyl, C2-4-alkenyl, C2-4-alkinyl, NH2, C1-4-alkyl-NH—, (C1-4-alkyl)2N—, C1-4-alkyl-O—, C1-4-alkyl-S—, C1-4-alkyl-S(═O)—, or C1-4-alkyl-S(═O)2;
• R3 is F, Cl, Br, I, CN, OH, C1-4-alkyl, C3-6-cycloalkyl, HO—C1-4-alkyl, C1-4-alkyl-O—C1-4-alkyl, —NRNH, C1-4-alkyl-NRN—, C1-4-alkyl-O—, C3-6-cycloalkyl-O—, C1-4-alkyl-O—C1-4-alkyl-O—, C1-4-alkyl-S—, C1-4-alkyl-S(═O)—, or C1-4-alkyl-S(═O)2—, wherein any alkyl and cycloalkyl group is optionally substituted with 1 or more F atoms;
• R4 is Cl, Br, I, C1-4-alkyl, CN, C3-6-cycloalkyl, C1-4-alkyl-C(═O)—, heterocyclyl-O(O)—, H2N—C(═O)—, C1-4-alkyl-NRN—C(═O)—, C3-6-cycloalkyl-NRN—C(═O)—, heterocyclyl-NRN—C(═O)—, phenyl—NRN—C(═O)—, heteroaryl—NRN—C(═O)—, HO—C(═O)—, C1-4-alkyl-O—C(═O)—, —NHRN, C1-4-alkyl-NRN—, C1-4-alkyl-C(═O)NRN—, C3-6-cycloalkyl-C(═O)NRN—, heterocyclyl-O(O)NRN—, phenyl-C(═O)NRN—, heteroaryl-C(═O)NRN—, C1-4-alkyl-S(═O)2NRN—, C3-6-cycloalkyl-S(═O)2NRN—, heterocyclyl-S(═O)2NRN—, phenyl-S(═O)2NRN—, heteroaryl-S(═O)2NRN—, —OH, C1-4-alkyl-O—, C1-4-alkyl-O—C1-4-alkyl-O—, O3-6-cycloalkyl-O—, heterocyclyl-O—, phenyl-O—, heteroaryl-O—, C1-4-alkyl-S—, C3-6-cycloalkyl-S—, heterocyclyl-S—, phenyl-S—, heteroaryl-S—, C1-4-alkyl-S(═O)—, C3-6-cycloalkyl-S(═O)—, heterocyclyl-S(═O)—, phenyl-S(═O)—, heteroaryl-S(═O)—, C1-4-alkyl-S(═O)2—, C3-6-cycloalkyl-S(═O)2—, heterocyclyl-S(═O)2—, phenyl-S(═O)2—, heteroaryl-S(═O)2—, H2N-S(═O)2—, C1-4-alkyl-NRN—S(═O)2—, heterocyclyl, phenyl, or heteroaryl,
• wherein any alkyl, cycloalkyl, and heterocyclyl group is optionally substituted with 1 or more F atoms and optionally substituted with 1 or 2 groups independently selected from H3C—, HO—, H3C—O—, and —CN, heterocyclyl is a C4-6-cycloalkyl group wherein 1 CH2 group is replaced by NRN, O, S, S(═O), or S(═O)2 and/or 1>CH— group is replaced by N, or 1 CH2 group is replaced by NRN, O, or S, and/or 1>CH— group is replaced by N, and 1 additional CH2 group is replaced by C(═O) or S(═O)2, and heteroaryl is (i) tetrazolyl, (ii) pyridinonyl, (iii) a 5-membered heteroaromatic ring containing 1 ring member selected from NRN, O, and S, or containing 1 N and 1 ring member selected from NRN, O, and S, or containing 1 NRN, O, or S and 2 N, and (iv) a 6-membered heteroaromatic ring which contains 1 to 3 N atoms, and each heteroaryl group is optionally substituted with 1 to 3 substituents independently selected from F, Cl, —CH3, —CN, and —O—CH3;
• R5 is F, Cl, Br, CN, C1-4-alkyl, cyclopropyl, F3C—, HO—C1-4-alkyl-, C1-4-alkyl-O—C1-4-alkyl-, C1-4-alkyl-O—, F3C—O—, —S(═O)—C1-4-alkyl, or S(═O)2-C1-4-alkyl;
• and
• RN is H, C1-4-alkyl, C1-4-alkyl-C(═O)—, C1-4-alkyl-NH—C(═O)—, C1-4-alkyl-N(C1-4-alkyl)-C(═O)—, C1-4-alkyl-O—C(═O)—, or C1-4-alkyl-S(═O)2—,
• wherein any alkyl group or sub-group is straight-chained or branched, unless specified otherwise,
• or a salt thereof.