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US 2016/0235704 A1Published application
Antimicrobial titanium dioxide nanoparticles functionalized with cationic silver ions
AssigneePavia Farmaceutici S.R.L.
InventorsMassimo FERRARI, Carlo Alberto BIGNOZZI, Valeria DISSETTE, Giuliana DI LALLO
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Abstract
The present invention generally relates to Titanium dioxide derivatives of formula TiO2-[L]-Ag+, functionalized with silver cations by a bifunctional mercapto alkylsilane ligand. The present derivatives are useful e.g. as antimicrobic, antiseptic and/or antiviral agent, in particular in the form of pharmaceutical compositions for topical use.
Claims20
A derivative of formula (I):
- TiO2-[L]-Ag+ (I)
- wherein:
- -[L]- is a bivalent mercapto alkyl silane ligand of general formula:
- -[Si—R—S]-, wherein R is a bivalent C1-C4 linear or branched alkyl group, optionally substituted;
- TiO2 represent a titanium dioxide particle linked to the silica atom of the ligand -[L]-;
- and
- Ag+ represents silver ions coordinated to the sulphur atom of the bivalent ligand -[L]-.
4 more elements
The derivative of formula (I) according to claim 5, wherein the silver ions are present in an amount ranging from 0.5 to 3% w/w.
A process for the preparation of formula (I)
- TiO2-[L]-Ag+ (I)
- wherein:
- -[L]- is a bivalent mercapto alkyl silane ligand of general formula:
- -[Si—R—S]-, wherein R is a bivalent C1-C4 linear or branched alkyl group, optionally substituted;
- TiO2 represent a titanium dioxide particle linked to the silica atom of the ligand -[L]-;
- and
- Ag+ represents silver ions coordinated to the sulphur atom of the bivalent ligand -[L]-;
- said process comprising the reaction of the titanium dioxide with a trialklyoxy mercaptosilane derivative of formula (II), in the presence of a silver salt (III):
- wherein:
- R is as defined above
- R′ is independently selected from C1-C4 monovalent linear or branched alkyl group, optionally substituted;
- Y− is an anionic counterion.
9 more elements
Dependencies are inferred from the claim text.