Back to results
US 2016/0235691 A1Published application
Non-Racemic Mixtures of Various Ratios of D- and L-methadone and Methods of Treating Pain Using the Same
OwnerY. Eugene MIRONERinventor
Life of this patent
Estimating the term…
Loading patent…
Loading patent…
OwnerY. Eugene MIRONERinventor
Estimating the term…
Non-racemic mixtures of D- and L-methadone containing a ratio ranging from about 2.5:1 to about 3.5:1 by weight of D-methadone to L-methadone, such as for example about 2.9:1 to about 3.1:1 by weight of D-methadone to L-methadone, or about 3:1 by weight of D-methadone to L-methadone, have been found to exhibit surprising and unexpected beneficial results in the treatment of neuropathic pain. Additionally, non-racemic mixtures of D- and L-methadone containing a ratio ranging from about 2.5:1 to about 3.5:1 by weight of D-methadone to L-methadone, about 2.9:1 to about 3.1:1 by weight of D-methadone to L-methadone, or for example about 3:1 by weight of D-methadone to L-methadone, in combination with other non-methadone opioids have been found to exhibit surprising and unexpected beneficial results in the treatment of mixed pain.
A pharmaceutical composition comprising a non-racemic mixture of D-methadone or pharmaceutically acceptable salt thereof and L-methadone or pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier, wherein the D-methadone or pharmaceutically acceptable salt thereof and L-methadone or pharmaceutically acceptable salt thereof are present in a ratio range from about 2.5:1 to about 3.5:1.
A pharmaceutical composition comprising a non-racemic mixture of D-methadone or pharmaceutically acceptable salt thereof and L-methadone or pharmaceutically acceptable salt thereof, at least one non-methadone opioid and a pharmaceutically acceptable carrier, wherein the D-methadone or pharmaceutically acceptable salt thereof and L-methadone or pharmaceutically acceptable salt thereof are present in a ratio range from about 2.5:1 to about 3.5:1.
The pharmaceutical composition according to claim 13, wherein the ratio of D-methadone to L-methadone is in the range from about 2.9:1 to about 3.1:1.
Dependencies are inferred from the claim text.