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US 2016/0235688 A1Published application
Device for formulating particles at small volumes
AssigneeThe University of British Columbia
InventorsColin Walsh, Andre Wild, Robert James Taylor, Timothy Leaver, Kevin Ou, Euan Ramsay, Aysha Ansari
Life of this patent
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Abstract
Methods and devices for making particles at small volumes.
Claims38
A method for making particles, comprising:
- (a) introducing a first stream comprising a first solvent into a channel;
- wherein the channel has a first region adapted for flowing one or more streams introduced into the channel and a second region for mixing the contents of the one or more streams;
- and wherein the first solvent comprises a therapeutic material and optionally one or more particle-forming materials;
- (b) introducing a second stream comprising one or more particle-forming materials and optionally a therapeutic material in a second solvent into the channel to provide first and second streams and wherein the first and second solvents are not the same;
- (c) flowing the one or more first streams and the one or more second streams from the first region of the channel into the second region of the channel such that the one or more first streams and the one or more second streams arrive at the second region for mixing at substantially the same time;
- and
- (d) mixing the contents of the one or more first streams and the one or more second streams in the second region of the channel to provide a third stream comprising particles.
4 more elements
A method for making particles, comprising:
- (a) introducing a stream comprising a first solvent into a channel;
- wherein the channel has a first region adapted for flowing one or more streams introduced into the channel;
- and
- (b) conducting the first stream through the channel and into a reservoir comprising a second solvent,
- wherein conducting the first stream into the reservoir comprises mixing the contents of the first stream with the contents of the reservoir to provide particles.
2 more elements
A device, comprising:
- (a) a first well for receiving a first solution comprising a first solvent;
- (b) a first channel in fluid communication with the first well;
- (c) a second well for receiving a second solution comprising a second solvent;
- (d) a second channel in fluid communication with the second well;
- (e) a third channel for receiving first and second streams flowed from the first and second wells through the first and second channels, respectively, wherein the third channel has a first region adapted for flowing the first and second streams introduced into the channel and a second region adapted for mixing the contents of the first and second streams to provide a third stream comprising particles;
- and
- (f) a third well for receiving the third stream comprising particles.
4 more elements
A device, comprising:
- (a) a first well for receiving a first solution comprising a first solvent;
- (b) a first channel in fluid communication with the first well;
- and
- (c) a second well for receiving a second solution comprising a second solvent, wherein the second well further receives a first stream flowed from the first well through the first channel, and wherein the second well is adapted for mixing the contents of the first stream and second solution in the second well to provide a third solution comprising particles.
1 more element
Dependencies are inferred from the claim text.